Endocrine Abstracts

Background: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of progressive liver diseases driven in part by macrophages, occurring in the absence of excessive alcohol consumption that ranges from simple steatosis to non-alcoholic steato-hepatitis (NASH), ultimately progressing to fibrosis/cirrhosis and hepatocellular carcinoma. NAFLD is associated with insulin resistance and confers an increased risk of cardiovascular disease. Pre-menopausal women are protected against...

Background: Insulin resistance and ageing are risk factors for the development of type 2 diabetes and atherosclerosis. Insulin signalling in macrophages affects their inflammatory responses and foam cell formation capacity, yet the mechanisms linking these remain unclear. Recent evidence has emerged linking macrophage lipid metabolism and inflammatory response such as an interferon-cholesterol pathway flux axis. Insulin has been shown to directly regulate chol...